Boku no Placebo was originally created after a allusion to yaoi hands on a post about Fisheye Placebo on December 27 2012. Leo is presumed to be the rival bishie trying to steal Frey from Vance-kun. On February 11, 2013, Yuumei had to take a break from drawing due to her swelling hands; it was speculated that this was due to Yaoi hand syndrome. Thankfully this illness was cured by watching Yuri. In the months surrounding the intial post, many fanart depictions were drawn and uploaded to the internet under the hastag '#boku no placebo'. On June 21, 2013, a Jack Block x Boku no Placebo crossover was written to critical acclaim.
Works depicting Boku no Placebo are always shown with Frey as the Uke and Vance as the seme. The reason for this is most likely due to Frey looking like a girl to the point of passing as one when crossdressing. A Boku no Placebo theme for the popular microblogging site, Tumblr, has also been created.