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On February 11, 2013, Yuumei had to take a break from drawing due to her swelling hands; it was speculated that this was due to Yaoi hand syndrome. Thankfully this illness was cured by watching Yuri. In the months surrounding the initial post, many fanart depictions were drawn and uploaded to the internet under the hastag '#boku no placebo'. On June 21, 2013, a Jack Block x Boku no Placebo crossover was written to critical acclaim. On October 7, 2013, a beautiful Boku no Placebo fanfiction was written in Russian.
It is currently unknown whether Boku no Placebo is canon or not. A post in Yuumei's Tumblr shows a cosplay of Vance kissing Frey under which she writes in strikethrough text: 'this is now canon'. It is unknown whether she made the photo; nor do we know if it is a joke.
Frey's sexual orientation has yet to be written about; however, we do know that he crossdresses, and although this is quite trivial, at one time he obviously wasn't distracted when a girl was dressing in front of him. Vance, on the other hand, acts as a straight guy. He is not considering seeking out a male partner, even though he is a desperate virgin at the age of 18.
The legal status of gays in CERia is unkown as well. However, depictions of yaoi are censored in the entire nation, so it is likely that homosexuality itself is illegal as well.
In all depictions of Boku no Placebo to date, Frey is always shown as the uke and Vance as the seme. The reason for this is most likely due to Frey looking like a girl to the point of passing as one when crossdressing. A Boku no Placebo theme for the popular microblogging site, Tumblr, has also been created.